Air Medical Journal
Volume 25, Issue 3 , Pages 124-126 , May 2006

Brugada syndrome: Silent assassin

  • Mike A. MacKinnon, CEN, CFRN, BSN, RN

      Affiliations

    • Corresponding Author InformationAddress for correspondence: Mike A. MacKinnon, Air Evac Services, 1242 E Mcdowell Rd, Phoenix, AZ 85006

References 

  1. Vatta M , Dumaine R , Varghese G , Richard TA , Shimizu W , Aihara N , et al.   Genetic and biophysical basis of sudden unexplained nocturnal death syndrome (SUNDS), a disease allelic to Brugada Syndrome . Hum Mol Genet . 2002;11:337–345
  2. Brugada J , Brugada R , Brugada P . Brugada syndrome . Arch Mal Coeur Vaiss . 1999;92:847–850
  3. Brugada J , Brugada P . Right bundle branch block, persistent ST-segment elevation in leads V1 through V3: a marker for sudden death in patients without demonstrable structural heart disease . Circulation . 1998;97:457–460
  4. Towbin JA . Cardiac arrhythmias: the genetic connection . J Cardiovasc Electrophysiol . 2000;11:601–602
  5. Wilde AA , Priori SG . Brugada syndrome and sudden death . Eur Heart J . 2000;21:1483
  6. Chen Q , Kirsch GE , Zhang D , Brugada R , Brugada J , Brugada P , et al.   Genetic basis and molecular mechanism for idiopathic ventricular fibrillation . Nature . 1998;392:293–296
  7. Antzelevitch C . The Brugada syndrome . J Cardiovasc Electrophysiol . 1998;9:513–516
  8. Priori SG , Napolitano C , Gasparini M , Pappone C , Della Bella P , Giordano U , et al.   Natural history of Brugada syndrome: insights for risk stratification and management . Circulation . 2002;105:1342–1347
  9. Rivolta I , Abriel H , Tateyama M , Liu H , Memmi M , Vardas P , et al.   Inherited Brugada and long QT-3 syndrome mutations of a single challenge residue of the cardiac sodium channel confer distinct channel and clinical phenotypes . J Biol Chem . 2001;276:30623–30630
  10. Veldkanp MW , Wilders R , Baartscheer A , Zegers JG , Bezzina CR , Wilde AAM . Contributions of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 families . Circ Res . 2003;92:976–983
  11. Priori SG , Napolotano C , Schwartz PJ , Bloise R , Crotti L , Ronchetti E . The elusive link between LQT3 and Brugada syndrome: the role of flecainide challenge . Circulation . 2000;102:945–947
  12. Alings M , Wilde A . Brugada syndrome: clinical data and suggested pathophysiological mechanism . Circulation . 1999;99:666–673

PII: S1067-991X(06)00018-6

doi: 10.1016/j.amj.2006.02.006

Air Medical Journal
Volume 25, Issue 3 , Pages 124-126 , May 2006

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